Two scientific studies show similar beneficial results of spinal manipulative therapy for infantile colic. In both studies crying from colic was reduced by two thirds. Wigerg DC, Nordsteen DC, Nilsson DC, MD, PhD. JMPT 1999;22(8):517-22 [This was a randomized control clinical trial with a blinded observer] and Klougart et al. JMPT1989;21(4):281-8.
The studies were strengthened when the data was reviewed in Wiberg et al. Evidence-Based Nursing 2000;3(2):12. It showed that the control group given dimethicone had almost a 20% drop-out rate because of worsening symptoms. The spinal manipulation group had no drop-outs. These drop-outs in the controls were not counted giving the control group better results than what were true.
Infantile colic is often caused, in part, by cow milk allergy. Soy or lactose free substitutes are usually not helpful but hypoallergenic formulas may be useful. Medications have more serious side effects than value in helping. Lucassen PLBJ, Assendelft WJJ, et al. Effectiveness of treatments for infantile colic: systematic review. British Medical Journal, May 23, 1998; 316(7144), pp 1563-1569.