Six hundred milligrams per day of magnesium supplementation reduced the frequency of migraine attacks by 46%. The number of days with migraine headache were also significantly reduced. Peikert A, Wilmzig C, Kohne-Volland R. Prophylaxis of migraine with oral magnesium: results from a prospective, multi-center, placebo-controlled and double-blind randomized study. Cephalgia, 1996; 6, pp 257-63.
The herb, Feverfew, is successful in reducing the severity of attacks. The usual dose 50-80 mg of the freeze dried leaves containing .4%-.66% of the active ingredient, parthenolide, per day. It usually takes 4-6 weeks to take effect. Murphy JJ et al. Randomized double-blind placebo-controlled trial of feverfew in migraine prevention. Lancet ii: 189-92, 1988. Johnson ES et al. Efficacy of feverfew as prophylactic treatment of migraine. British Medical Journal 291:569-73, 1985.